Melanocortin-4 receptors, β-MSH and leptin: key elements in the satiety pathway

JA Harrold, G Williams - Peptides, 2006 - Elsevier
This paper reviews aspects of our research, focusing on the role of the melanocortin system
in the central regulation of feeding and energy balance, which was begun in 1997. It
describes data from successive physiological studies, concerning the identity of the appetite-
regulating melanocortin receptor, melanocortin-4 receptor (MC4R) regulation with altered
nutritional status, the role of MC4R in dietary obesity and the identity of the endogenous
MC4R ligand.