Cold response of the bladder in guinea pig: involvement of transient receptor potential channel, TRPM8
Y Tsukimi, K Mizuyachi, T Yamasaki, T Niki, F Hayashi - Urology, 2005 - Elsevier
OBJECTIVES: To address the physiologic role of TRPM8, one of the transient receptor
potential channels, we investigated the bladder cooling reflex and the effect of menthol on it
in the guinea pig. METHODS: Single cystometry in female Hartley guinea pigs was
performed with high-speed infusion (60 mL/hr) under urethane anesthesia (1 g/kg
intraperitoneally). The volume threshold for micturition (VT) and micturition pressure were
determined. The distribution of TRPM8 in the S1 dorsal root ganglion (DRG) was also …
potential channels, we investigated the bladder cooling reflex and the effect of menthol on it
in the guinea pig. METHODS: Single cystometry in female Hartley guinea pigs was
performed with high-speed infusion (60 mL/hr) under urethane anesthesia (1 g/kg
intraperitoneally). The volume threshold for micturition (VT) and micturition pressure were
determined. The distribution of TRPM8 in the S1 dorsal root ganglion (DRG) was also …
