[HTML][HTML] Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing
Mutations in genes encoding presenilins (PS1 and PS2) cosegregate with the majority of
early onset cases of familial Alzheimer's disease. PS1 and PS2 are polytopic membrane
proteins that undergo endoproteolytic cleavage to generate stable NH 2-and COOH-terminal
derivatives (NTF and CTF, respectively). Several lines of evidence suggest that the
endoproteolytic derivatives are likely the functional units of PSin vivo. In the present report,
we examine the disposition of PS NTF and CTF assemblies in stable mouse N2a …
early onset cases of familial Alzheimer's disease. PS1 and PS2 are polytopic membrane
proteins that undergo endoproteolytic cleavage to generate stable NH 2-and COOH-terminal
derivatives (NTF and CTF, respectively). Several lines of evidence suggest that the
endoproteolytic derivatives are likely the functional units of PSin vivo. In the present report,
we examine the disposition of PS NTF and CTF assemblies in stable mouse N2a …
