Basic mechanisms in congestive heart failure: recognizing the role of proinflammatory cytokines

DL Mann, JB Young - Chest, 1994 - journal.chestnet.org
CIIF= congestin• heart failure; eNOS= constitutive nitric oxide s\· nthesis; IL-l= interleukin-1;
IL-lra= interleukin-1 receptor antagonist; IL-6= interleukin-6; IL-8= interleukin-8; iNOS=
inducible nitric oxide svnthcsis; LV= left ventricle; NO= nitric oxide; TNFa;, tumor necrosis
factor-alpha; TNFRl= tumor necrosis factor receptor 1; TNFR2= tumor necrosis factor
receptor 2 Three basic pathophysiologic conditions are responsible for tlw development of
heart failure in man: pressure on· rload.,-olume overload, and primary myocardial disease …