Platelet-mediated lymphocyte delivery to high endothelial venules
TG Diacovo, KD Puri, RA Warnock, TA Springer… - Science, 1996 - science.org
Science, 1996•science.org
Circulating lymphocytes gain access to lymph nodes owing to their ability to initiate rolling
along specialized high endothelial venules (HEVs). One mechanism of rolling involves L-
selectin binding to peripheral node addressin (PNAd) on HEVs. Activated platelets are
shown to bind to circulating lymphocytes and to mediate rolling in HEVs, in vivo, through
another molecule, P-selectin, which also interacts with PNAd. In vitro, activated platelets
enhanced tethering of lymphocytes to PNAd and sustained lymphocyte rolling, even in the …
along specialized high endothelial venules (HEVs). One mechanism of rolling involves L-
selectin binding to peripheral node addressin (PNAd) on HEVs. Activated platelets are
shown to bind to circulating lymphocytes and to mediate rolling in HEVs, in vivo, through
another molecule, P-selectin, which also interacts with PNAd. In vitro, activated platelets
enhanced tethering of lymphocytes to PNAd and sustained lymphocyte rolling, even in the …
Circulating lymphocytes gain access to lymph nodes owing to their ability to initiate rolling along specialized high endothelial venules (HEVs). One mechanism of rolling involves L-selectin binding to peripheral node addressin (PNAd) on HEVs. Activated platelets are shown to bind to circulating lymphocytes and to mediate rolling in HEVs, in vivo, through another molecule, P-selectin, which also interacts with PNAd. In vitro, activated platelets enhanced tethering of lymphocytes to PNAd and sustained lymphocyte rolling, even in the absence of functional L-selectin. Thus, a platelet pathway operating through P-selectin provides a second mechanism for lymphocyte delivery to HEVs.
AAAS