Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis
YK Chou, DN Bourdette, H Offner, R Whitham… - Journal of …, 1992 - Elsevier
T cell sensitization to two myelin components, myelin basic protein (MBP) and myelin
proteolipid protein (PLP), may be important to the pathogenesis of multiple sclerosis (MS).
Using the limiting dilution assay, we demonstrated that the blood of MS patients had an
increased frequency of MBP-reactive T cells compared with normal subjects and patients
with other neurological diseases (OND) and rheumatoid arthritis. There was no difference in
T cell frequency to a synthetic peptide, PLP 139− 151, or Herpes simplex virus. Within …
proteolipid protein (PLP), may be important to the pathogenesis of multiple sclerosis (MS).
Using the limiting dilution assay, we demonstrated that the blood of MS patients had an
increased frequency of MBP-reactive T cells compared with normal subjects and patients
with other neurological diseases (OND) and rheumatoid arthritis. There was no difference in
T cell frequency to a synthetic peptide, PLP 139− 151, or Herpes simplex virus. Within …