Virus-reactive and autoreactive T cells are accumulated in cerebrospinal fluid in multiple sclerosis
H Link, JB Sun, Z Wang, Z Xu, A Löve… - Journal of …, 1992 - Elsevier
Elevated numbers of B cells—plasma cells secreting antibodies to measles and mumps
virus, and to myelin associated glycoprotein (MAG), one of several putative myelin
autoantigens—have previously been reported in cerebrospinal fluid (CSF) from patients with
multiple sclerosis (MS), while it is unknown if corresponding T cell reactivities occur. We
have defined the T cell reactivities to measles and mumps virus and to MAG in an
immunospot assay which is based on the detection of secretion of interferon-gamma (IFN-γ) …
virus, and to myelin associated glycoprotein (MAG), one of several putative myelin
autoantigens—have previously been reported in cerebrospinal fluid (CSF) from patients with
multiple sclerosis (MS), while it is unknown if corresponding T cell reactivities occur. We
have defined the T cell reactivities to measles and mumps virus and to MAG in an
immunospot assay which is based on the detection of secretion of interferon-gamma (IFN-γ) …