Recent evidence suggests that hippocampal damage can be both the result of seizure
activity and the cause of further chronic epilepsy. A review of current models of status
epilepticus-induced brain damage reveals that excitotoxic mechanisms probably mediate
the lesions in most brain regions. NMDA receptors appear to play a dominant role, although
non-NMDA glutamate receptors are important in several specific neuronal populations. In
the immature brain, a number of unique metabolic features determine a different set of …