[HTML][HTML] The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin
T Osterwalder, P Cinelli, A Baici, A Pennella… - Journal of Biological …, 1998 - ASBMB
Neuroserpin is an axonally secreted serine proteinase inhibitor that is expressed in neurons
during embryogenesis and in the adult nervous system. To identify target proteinases, we
used a eucaryotic expression system based on the mouse myeloma cell line J558L and
vectors including a promoter from an Ig-κ-variable region, an Ig-κ enhancer, and the exon
encoding the Ig-κ constant region (Cκ) and produced recombinant neuroserpin as a wild-
type protein or as a fusion protein with Cκ. We investigated the capability of recombinant …
during embryogenesis and in the adult nervous system. To identify target proteinases, we
used a eucaryotic expression system based on the mouse myeloma cell line J558L and
vectors including a promoter from an Ig-κ-variable region, an Ig-κ enhancer, and the exon
encoding the Ig-κ constant region (Cκ) and produced recombinant neuroserpin as a wild-
type protein or as a fusion protein with Cκ. We investigated the capability of recombinant …
