Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death
B Liu, N Andrieu-Abadie, T Levade, P Zhang… - Journal of Biological …, 1998 - ASBMB
Tumor necrosis factor-α (TNFα)-induced cell death involves a diverse array of mediators and
regulators including proteases, reactive oxygen species, the sphingolipid ceramide, and Bcl-
2. It is not known, however, if and how these components are connected. We have
previously reported that GSH inhibits, in vitro, the neutral magnesium-dependent
sphingomyelinase (N-SMase) from Molt-4 leukemia cells. In this study, GSH was found to
reversibly inhibit the N-SMase from human mammary carcinoma MCF7 cells. Treatment of …
regulators including proteases, reactive oxygen species, the sphingolipid ceramide, and Bcl-
2. It is not known, however, if and how these components are connected. We have
previously reported that GSH inhibits, in vitro, the neutral magnesium-dependent
sphingomyelinase (N-SMase) from Molt-4 leukemia cells. In this study, GSH was found to
reversibly inhibit the N-SMase from human mammary carcinoma MCF7 cells. Treatment of …
