Study objectives Evaluate the safety of filgrastim (recombinant methionyl human granulocyte
colony-stimulating factor) administration, combined with standard therapy, in patients
withpneumonia and either septic shock or severe sepsis who were receivingmechanical
ventilation. Design Multicenter, double-blind, randomized, placebo-controlled study. Setting
ICU, multicenter. Patients Eighteen patients with pneumonia and hypotension, or in the
absence ofshock, two or more end-organ dysfunctions, were enrolled and treated. Baseline …