A locus for adolescent and adult onset familial focal segmental glomerulosclerosis on chromosome 1q25-31
H Tsukaguchi, H Yager, J Dawborn, L Jost… - Journal of the …, 2000 - journals.lww.com
Focal segmental glomerulosclerosis is a nonspecific renal lesion observed both as a
primary (idiopathic) entity and in a secondary form, typically in association with reduced
functional renal mass. Familial forms have been observed and two loci for autosomal
dominant FSGS have been mapped. This study shows that an adolescent/adult form of
recessive FSGS maps to a locus on chromosome 1q25-31, which overlaps with a region
previously identified as harboring a locus for an early childhood onset recessive form of …
primary (idiopathic) entity and in a secondary form, typically in association with reduced
functional renal mass. Familial forms have been observed and two loci for autosomal
dominant FSGS have been mapped. This study shows that an adolescent/adult form of
recessive FSGS maps to a locus on chromosome 1q25-31, which overlaps with a region
previously identified as harboring a locus for an early childhood onset recessive form of …