Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS
C Guegan, M Vila, P Teissman, C Chen… - Molecular and Cellular …, 2002 - Elsevier
Transgenic expression of mutant superoxide dismutase-1 (SOD1) produces an animal
model of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. We have
previously shown that the mitochondrial-dependent programmed cell death (PCD) pathway,
including the redistribution of Bax, the cytosolic release of cytochrome c, and the activation
of caspase-9, is recruited during neurodegeneration in spinal cords of transgenic mutant
SOD1 mice. Herein, we show that the pro-PCD protein Bid is highly expressed in spinal …
model of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. We have
previously shown that the mitochondrial-dependent programmed cell death (PCD) pathway,
including the redistribution of Bax, the cytosolic release of cytochrome c, and the activation
of caspase-9, is recruited during neurodegeneration in spinal cords of transgenic mutant
SOD1 mice. Herein, we show that the pro-PCD protein Bid is highly expressed in spinal …
