Study objectives To review the available data on the early detection of lung cancer, with a
focus on three technologies: chest x-ray (CXR), sputum cytology, and low-dose CT (LDCT)
scanning. Design, setting, participants Review of published clinical studies of early detection
technologies. The best available evidence on each topic was selected for analysis.
Randomized trials were used to evaluate CXR and sputum cytology. Cohort studies, as well
as studies providing evidence regarding rates of overdiagnosis and efficacy of initial …