Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome
NA Jenkins, NG Copeland, BA Taylor, BK Lee - Nature, 1981 - nature.com
NA Jenkins, NG Copeland, BA Taylor, BK Lee
Nature, 1981•nature.comThe single endogenous DBA/2J ecotropic provirus segregated concordantly with the dilute
(d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred
mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis
of DNA from a spontaneous DBA/2J d revenant (d+ 2J) showed that these mice lack
ecotropic-specific MuLV DNA sequences and suggested that the dilute mutation resulted
from integration of an ecotropic provirus into the mouse genome.
(d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred
mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis
of DNA from a spontaneous DBA/2J d revenant (d+ 2J) showed that these mice lack
ecotropic-specific MuLV DNA sequences and suggested that the dilute mutation resulted
from integration of an ecotropic provirus into the mouse genome.
Abstract
The single endogenous DBA/2J ecotropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revenant (d+2J) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute mutation resulted from integration of an ecotropic provirus into the mouse genome.
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