Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases
JC Hutton - Diabetologia, 1994 - Springer
JC Hutton
Diabetologia, 1994•SpringerThe insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi
network from around 50 or so gene products many of which are synthesized coordinately
with the major component, proinsulin. An important contribution to our understanding of the
regulation of this process has come from studies of the post-translational processing of
proinsulin and of other proteins which are stored in the granule, particularly the processing
enzymes themselves. The present review focusses on recent insights into the molecular …
network from around 50 or so gene products many of which are synthesized coordinately
with the major component, proinsulin. An important contribution to our understanding of the
regulation of this process has come from studies of the post-translational processing of
proinsulin and of other proteins which are stored in the granule, particularly the processing
enzymes themselves. The present review focusses on recent insights into the molecular …
Summary
The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin. An important contribution to our understanding of the regulation of this process has come from studies of the post-translational processing of proinsulin and of other proteins which are stored in the granule, particularly the processing enzymes themselves. The present review focusses on recent insights into the molecular nature of the processing machinery, and the granule Ca2+-dependent subtilisin-related endopeptidases which catalyse the initial rate-limiting step in the enzymic conversion of proinsulin.
Springer
