Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase
JWHP van de Loo, JWM Creemers, NA Bright… - Journal of Biological …, 1997 - ASBMB
Proprotein convertases are responsible for the endoproteolytic processing of prohormones,
neuropeptide precursors, and other proproteins within the constitutive and regulated
secretory pathways. Cleavage occurs carboxyl-terminally of basic amino acid motifs, such as
RX (K/R) R, RXXR, and (R/K) R. As already available for the other known mammalian
members of this enzyme family, we here define structural and functional features of human
lymphoma proprotein convertase (LPC). Analysis of expression of recombinant LPC in …
neuropeptide precursors, and other proproteins within the constitutive and regulated
secretory pathways. Cleavage occurs carboxyl-terminally of basic amino acid motifs, such as
RX (K/R) R, RXXR, and (R/K) R. As already available for the other known mammalian
members of this enzyme family, we here define structural and functional features of human
lymphoma proprotein convertase (LPC). Analysis of expression of recombinant LPC in …
