[HTML][HTML] p21-activated Kinase 1 Activates the Nuclear Factor κB (NF-κB)-inducing Kinase-IκB Kinases NF-κB Pathway and Proinflammatory Cytokines in Helicobacter …
A Foryst-Ludwig, M Naumann - Journal of Biological Chemistry, 2000 - ASBMB
Helicobacter pylori, the causative agent of several human gastric diseases, induces
activation of the immediate early response transcription factor nuclear factor κB (NF-κB),
which subsequently triggers release of proinflammatory cytokines in colonized epithelial
cells. Here we report that inH. pylori infection p21-activated kinase 1 (PAK1) activates NF-
κB. Activated PAK1 associates with NF-κB-inducing kinase, which upon activation directs the
activity of IκB kinases to IκBα. Our results indicate that in epithelial cells PAK1 participates in …
activation of the immediate early response transcription factor nuclear factor κB (NF-κB),
which subsequently triggers release of proinflammatory cytokines in colonized epithelial
cells. Here we report that inH. pylori infection p21-activated kinase 1 (PAK1) activates NF-
κB. Activated PAK1 associates with NF-κB-inducing kinase, which upon activation directs the
activity of IκB kinases to IκBα. Our results indicate that in epithelial cells PAK1 participates in …