Publisher Summary DNA was primarily viewed as a blueprint for genetic information but
essentially as immunologically inert. Compelling evidence now shows that the prokaryotic
DNA—through pattern recognition—is sensed by cells of the immune system, thereby
signaling “infectious danger.” Central to its physiological relevance is the question whether
“sensing” of CpG DNA reflects an evolutionary vestige of the innate system to signal
infectious danger. If pathogen-derived CpG DNA is sensed and evaluated via pattern …