Regulation of Cytochrome P450 2C11 (CYP2C11) Gene Expression by Interleukin-1, Sphingomyelin Hydrolysis, and Ceramides in Rat Hepatocytes (∗)
J Chen, M Nikolova-Karakashian, AH Merrill… - Journal of Biological …, 1995 - ASBMB
Interleukin-1 triggers the down-regulation of several hepatic cytochrome P450 gene
products, but the cellular signaling pathways involved are not known. We have examined
the role of sphingomyelin hydrolysis to ceramide in the suppression of CYP2C11, a major
constitutive form of cytochrome P450, by interleukin-1. Treatment of rat hepatocytes cultured
on matrigel with interleukin-1β caused a rapid turnover of sphingomyelin and an increase in
cellular ceramide, with no change in cellular phosphatidylcholine. The ceramide was …
products, but the cellular signaling pathways involved are not known. We have examined
the role of sphingomyelin hydrolysis to ceramide in the suppression of CYP2C11, a major
constitutive form of cytochrome P450, by interleukin-1. Treatment of rat hepatocytes cultured
on matrigel with interleukin-1β caused a rapid turnover of sphingomyelin and an increase in
cellular ceramide, with no change in cellular phosphatidylcholine. The ceramide was …
