[HTML][HTML] The low density lipoprotein receptor prevents secretion of dense apoB100-containing lipoproteins from the liver
SL Larsson, J Skogsberg, J Björkegren - Journal of Biological Chemistry, 2004 - ASBMB
The assembly and secretion of very low density lipoproteins (VLDL) require microsomal
triglyceride transfer protein (MTP). Recent evidence also suggests a role for the low density
lipoprotein (LDL) receptor in this process. However, the relative importance of MTP in the
two steps of VLDL assembly and the specific role of the LDL receptor still remain unclear. To
further investigate the role of MTP and the LDL receptor in VLDL assembly, we bred mice
harboring" floxed" Mttp alleles (Mttp flox/flox) and a Cre transgene on a low-density …
triglyceride transfer protein (MTP). Recent evidence also suggests a role for the low density
lipoprotein (LDL) receptor in this process. However, the relative importance of MTP in the
two steps of VLDL assembly and the specific role of the LDL receptor still remain unclear. To
further investigate the role of MTP and the LDL receptor in VLDL assembly, we bred mice
harboring" floxed" Mttp alleles (Mttp flox/flox) and a Cre transgene on a low-density …
