[HTML][HTML] A proteomic approach identifies proteins in hepatocytes that bind nascent apolipoprotein B
KA Rashid, S Hevi, Y Chen, F Le Cahérec… - Journal of Biological …, 2002 - ASBMB
The biogenesis of apolipoprotein B is quite complex in view of its huge size, hydrophobicity,
obligate association with lipids such as cholesterol and triglycerides prior to secretion, and
intracellular degradation of a substantial proportion of newly synthesized molecules.
Multiple proteins likely serve roles as molecular chaperones to assist in folding, assembly
with lipids, and regulation of the secretion of apolipoprotein B. In these studies, we
developed a strategy to isolate proteins associated with apolipoprotein B in rat livers. The …
obligate association with lipids such as cholesterol and triglycerides prior to secretion, and
intracellular degradation of a substantial proportion of newly synthesized molecules.
Multiple proteins likely serve roles as molecular chaperones to assist in folding, assembly
with lipids, and regulation of the secretion of apolipoprotein B. In these studies, we
developed a strategy to isolate proteins associated with apolipoprotein B in rat livers. The …
