Targeting the central nervous system inflammatory response in ischemic stroke
KJ Becker - Current opinion in neurology, 2001 - journals.lww.com
Current opinion in neurology, 2001•journals.lww.com
In experimental models of stroke, inflammation appears to contribute to cerebral ischemic
injury. Clinical trials that are aimed at limiting the postischemic inflammatory response,
however, have thus far had disappointing results. These clinical failures probably reflect the
fact that there has been insufficient preclinical data and inadequate trial design, rather than
provide evidence against a role for inflammation in ischemic brain injury.
injury. Clinical trials that are aimed at limiting the postischemic inflammatory response,
however, have thus far had disappointing results. These clinical failures probably reflect the
fact that there has been insufficient preclinical data and inadequate trial design, rather than
provide evidence against a role for inflammation in ischemic brain injury.
Abstract
In experimental models of stroke, inflammation appears to contribute to cerebral ischemic injury. Clinical trials that are aimed at limiting the postischemic inflammatory response, however, have thus far had disappointing results. These clinical failures probably reflect the fact that there has been insufficient preclinical data and inadequate trial design, rather than provide evidence against a role for inflammation in ischemic brain injury.
Lippincott Williams & Wilkins