Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model
M Ueno, Y Moriyama, R Toda, G Yotsumoto… - The Journal of heart and …, 2001 - Elsevier
Background: Ischemia/reperfusion injury is a major cause of transplanted heart dysfunction.
Several reports have demonstrated that polymorphonuclear neutrophil (PMN) elastase
derived from the activated neutrophils might play an important role in this injury. Herein, we
investigated the protective effects of PMN elastase inhibitor (ONO-5046 Na) on
ischemia/reperfusion injury using a left-sided canine heterotopic heart transplantation
model. Methods: We used 10 pairs of adult beagle dogs. The donor heart was transplanted …
Several reports have demonstrated that polymorphonuclear neutrophil (PMN) elastase
derived from the activated neutrophils might play an important role in this injury. Herein, we
investigated the protective effects of PMN elastase inhibitor (ONO-5046 Na) on
ischemia/reperfusion injury using a left-sided canine heterotopic heart transplantation
model. Methods: We used 10 pairs of adult beagle dogs. The donor heart was transplanted …