Transient neonatal diabetes and later onset diabetes: a case of inherited insulin resistance.
JP Shield, JD Baum - Archives of disease in childhood, 1995 - adc.bmj.com
JP Shield, JD Baum
Archives of disease in childhood, 1995•adc.bmj.comA 13 year old girl who had had transient neonatal diabetes developed permanent diabetes.
She had raised fasting insulin concentrations suggestive of insulin resistance with a
suboptimal insulin response to glucose loading. Both her mother and sister had profound
insulin resistance; neither had clinical diabetes. This is the first time inherited insulin
resistance has been implicated in the pathogenesis of permanent diabetes developing after
transient neonatal diabetes.
She had raised fasting insulin concentrations suggestive of insulin resistance with a
suboptimal insulin response to glucose loading. Both her mother and sister had profound
insulin resistance; neither had clinical diabetes. This is the first time inherited insulin
resistance has been implicated in the pathogenesis of permanent diabetes developing after
transient neonatal diabetes.
A 13 year old girl who had had transient neonatal diabetes developed permanent diabetes. She had raised fasting insulin concentrations suggestive of insulin resistance with a suboptimal insulin response to glucose loading. Both her mother and sister had profound insulin resistance; neither had clinical diabetes. This is the first time inherited insulin resistance has been implicated in the pathogenesis of permanent diabetes developing after transient neonatal diabetes.
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