Sir–Transient neonatal diabetes mellitus (TNDM) classically occurs in growth retarded
infants in the first few weeks of life. The condition is usuallyselflimitingandmost patients
recoverbyoneyearofage. Subsequent insulin-dependent diabetes may occur in later
childhood. A failure of ß cell maturation has been proposed as the underlying defect"
although the real cause remains unknown. Individuals with TNDM do not appear to carry the
common HLA susceptibility haplotypes associated with childhood diabetes norevidence of …