[HTML][HTML] Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase
PA Ram, DJ Waxman - Journal of Biological Chemistry, 1997 - ASBMB
Growth hormone (GH) rapidly stimulates tyrosine phosphorylation followed by
serine/threonine phosphorylation of multiple cytoplasmic STAT transcription factors,
including one, STAT5b, that is uniquely responsive to the temporal pattern of plasma GH
stimulation in rat liver and is proposed to play a central role in the activation of male-
expressed liver genes by GH pulses in vivo (Waxman, DJ, Ram, PA, Park, SH, and Choi, HK
(1995) J. Biol. Chem. 270, 13262–13270). We now show that JAK2, the GH receptor …
serine/threonine phosphorylation of multiple cytoplasmic STAT transcription factors,
including one, STAT5b, that is uniquely responsive to the temporal pattern of plasma GH
stimulation in rat liver and is proposed to play a central role in the activation of male-
expressed liver genes by GH pulses in vivo (Waxman, DJ, Ram, PA, Park, SH, and Choi, HK
(1995) J. Biol. Chem. 270, 13262–13270). We now show that JAK2, the GH receptor …