[HTML][HTML] Acute control of insulin-like growth factor-I gene transcription by growth hormone through Stat5b
J Woelfle, J Billiard, P Rotwein - Journal of Biological Chemistry, 2003 - ASBMB
Many of the effects of growth hormone (GH) are mediated by insulin-like growth factor-I (IGF-
I), a secreted peptide whose gene transcription is induced by GH by unknown mechanisms.
Recent studies in mice have implicated Stat5b as part of a GH-regulated somatic growth
pathway, because mice lacking this transcription factor show diminished growth rates and a
decline in serum IGF-I levels. To test the role of Stat5b in GH-stimulated IGF-I gene
expression, we have delivered modified versions of the protein to pituitary-deficient male …
I), a secreted peptide whose gene transcription is induced by GH by unknown mechanisms.
Recent studies in mice have implicated Stat5b as part of a GH-regulated somatic growth
pathway, because mice lacking this transcription factor show diminished growth rates and a
decline in serum IGF-I levels. To test the role of Stat5b in GH-stimulated IGF-I gene
expression, we have delivered modified versions of the protein to pituitary-deficient male …
