[HTML][HTML] Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure
Y Sun, M Hao, Y Luo, C Liang, DL Silver… - Journal of Biological …, 2003 - ASBMB
Liver X receptor/retinoid X receptor (LXR/RXR) transcription factors have been found to
induce a number of genes involved in the regulation of cellular cholesterol efflux, including
the ATP-binding cassette transporter A1 (ABCA1), which mediates the active efflux of
cellular cholesterol and phospholipids to extracellular acceptors, such as apolipoprotein AI
(apoA-I). In a screen for macrophage LXR/RXR target genes, we identifiedstearoyl-CoA
desaturases 1 and 2 (Scd1 and Scd2), and subsequently tested the hypothesis that SCD …
induce a number of genes involved in the regulation of cellular cholesterol efflux, including
the ATP-binding cassette transporter A1 (ABCA1), which mediates the active efflux of
cellular cholesterol and phospholipids to extracellular acceptors, such as apolipoprotein AI
(apoA-I). In a screen for macrophage LXR/RXR target genes, we identifiedstearoyl-CoA
desaturases 1 and 2 (Scd1 and Scd2), and subsequently tested the hypothesis that SCD …
