[HTML][HTML] Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1
Y Wang, JF Oram - Journal of Biological Chemistry, 2002 - ASBMB
Abnormal high density lipoprotein metabolism may contribute to the increased
atherosclerosis associated with diabetes and insulin resistance. The ATP-binding cassette
transporter ABCA1 mediates cholesterol transport from tissue macrophages to apoA-I, the
major high density lipoprotein protein component. Because fatty acids are elevated in
diabetes, we examined the effects of fatty acids on ABCA1 activity in cultured macrophages.
Results showed that unsaturated fatty acids markedly inhibited ABCA1-mediated cholesterol …
atherosclerosis associated with diabetes and insulin resistance. The ATP-binding cassette
transporter ABCA1 mediates cholesterol transport from tissue macrophages to apoA-I, the
major high density lipoprotein protein component. Because fatty acids are elevated in
diabetes, we examined the effects of fatty acids on ABCA1 activity in cultured macrophages.
Results showed that unsaturated fatty acids markedly inhibited ABCA1-mediated cholesterol …