[HTML][HTML] Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-α (TNF-α) mRNA induction: evidence for selective destabilization of TNF-α …
K Rutault, CA Hazzalin, LC Mahadevan - Journal of Biological Chemistry, 2001 - ASBMB
Tumor necrosis factor-α (TNF-α) is a potent proinflammatory cytokine whose synthesis and
secretion are implicated in diverse pathologies. Hence, inhibition of TNF-α transcription or
translation and neutralization of its protein product represent major pharmaceutical
strategies to control inflammation. We have studied the role of ERK and p38 mitogen-
activated protein (MAP) kinase in controlling TNF-α mRNA levels in differentiated THP-1
cells and in freshly purified human monocytes. We show here that it is possible to produce …
secretion are implicated in diverse pathologies. Hence, inhibition of TNF-α transcription or
translation and neutralization of its protein product represent major pharmaceutical
strategies to control inflammation. We have studied the role of ERK and p38 mitogen-
activated protein (MAP) kinase in controlling TNF-α mRNA levels in differentiated THP-1
cells and in freshly purified human monocytes. We show here that it is possible to produce …