[HTML][HTML] Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein
K Gillotte-Taylor, A Boullier, JL Witztum… - Journal of lipid …, 2001 - ASBMB
Scavenger receptor class B type I (SR-BI) has been established as the primary mediator of
the selective transfer of lipids from HDL to mammalian cells. In addition to its role in
cholesterol metabolism, SR-BI has been shown to bind apoptotic cells and thus could in
theory also function as a scavenger receptor. We now show that SR-BI binds oxidized LDL
(OxLDL) with high affinity (K d of 4.0±0.5 μg/ml) and mediates internalization and
degradation to an extent comparable to that of other scavenger receptors, when normalized …
the selective transfer of lipids from HDL to mammalian cells. In addition to its role in
cholesterol metabolism, SR-BI has been shown to bind apoptotic cells and thus could in
theory also function as a scavenger receptor. We now show that SR-BI binds oxidized LDL
(OxLDL) with high affinity (K d of 4.0±0.5 μg/ml) and mediates internalization and
degradation to an extent comparable to that of other scavenger receptors, when normalized …
