Increased prostaglandin E2 concentrations and cyclooxygenase-2 expression in asthmatic subjects with sputum eosinophilia
M Profita, A Sala, A Bonanno, L Riccobono… - Journal of Allergy and …, 2003 - Elsevier
BACKGROUND: Prostaglandin E2 (PGE2) is known to be produced within human airways,
but it is not clear whether in airway diseases it can play a deleterious or a beneficial role.
Recently it has been reported that PGE2 can enhance eosinophil survival in vitro.
OBJECTIVE: To evaluate whether the concentrations of PGE2 in asthmatic airways correlate
with the number of eosinophils and can be responsible for eosinophil-enhanced survival
and to identify the cyclooxygenase isoform contributing to the synthesis of PGE2 by cells …
but it is not clear whether in airway diseases it can play a deleterious or a beneficial role.
Recently it has been reported that PGE2 can enhance eosinophil survival in vitro.
OBJECTIVE: To evaluate whether the concentrations of PGE2 in asthmatic airways correlate
with the number of eosinophils and can be responsible for eosinophil-enhanced survival
and to identify the cyclooxygenase isoform contributing to the synthesis of PGE2 by cells …
