SHP1 protein-tyrosine phosphatase inhibits gp91PHOXand p67PHOX expression by inhibiting interaction of PU. 1, IRF1, interferon consensus sequence-binding …
B Kautz, R Kakar, E David, EA Eklund - Journal of Biological Chemistry, 2001 - ASBMB
The CYBB and NCF2 genes encode the phagocyte respiratory burst oxidase proteins, gp91
PHOX and p67 PHOX. Previously, we identified homologous CYBB and NCF2 cis elements
that are necessary for lineage-specific transcription during late myeloid differentiation. We
determined that these homologous cis elements are activated by PU. 1, IRF1, interferon
consensus sequence-binding protein (ICSBP), and the CREB-binding protein (CBP). Since
expression of PU. 1 and ICSBP is lineage-restricted, our investigations identified a …
PHOX and p67 PHOX. Previously, we identified homologous CYBB and NCF2 cis elements
that are necessary for lineage-specific transcription during late myeloid differentiation. We
determined that these homologous cis elements are activated by PU. 1, IRF1, interferon
consensus sequence-binding protein (ICSBP), and the CREB-binding protein (CBP). Since
expression of PU. 1 and ICSBP is lineage-restricted, our investigations identified a …
