Transforming growth factor-β1 (TGF-β1) and TGF-β2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase …
J Han, DP Hajjar, JM Tauras, J Feng, AM Gotto… - Journal of Biological …, 2000 - ASBMB
CD36, the macrophage type B scavenger receptor, binds and internalizes oxidized low
density lipoprotein, a key event in the development of macrophage foam cells within
atherosclerotic lesions. Expression of CD36 in monocyte/macrophages is dependent on
differentiation status and exposure to soluble mediators. In this study, we investigated the
effect of transforming growth factor-β1 (TGF-β1) and TGF-β2 on the expression of CD36 in
macrophages. Treatment of phorbol ester-differentiated THP-1 macrophages with TGF-β1 or …
density lipoprotein, a key event in the development of macrophage foam cells within
atherosclerotic lesions. Expression of CD36 in monocyte/macrophages is dependent on
differentiation status and exposure to soluble mediators. In this study, we investigated the
effect of transforming growth factor-β1 (TGF-β1) and TGF-β2 on the expression of CD36 in
macrophages. Treatment of phorbol ester-differentiated THP-1 macrophages with TGF-β1 or …
