[HTML][HTML] Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity
MA Meyn, MB Wilson, FA Abdi, N Fahey… - Journal of Biological …, 2006 - ASBMB
Bcr-Abl is the oncogenic protein-tyrosine kinase responsible for chronic myelogenous
leukemia. Recently, we observed that inhibition of myeloid Src family kinase activity (eg Hck,
Lyn, and Fyn) induces growth arrest and apoptosis in Bcr-Abl-transformed cells, suggesting
that cell transformation by Bcr-Abl involves Src family kinases (Wilson, MB, Schreiner, SJ,
Choi, HJ, Kamens, J., and Smithgall, TE (2002) Oncogene 21, 8075-8088). Here, we report
the unexpected observation that Hck, Lyn, and Fyn strongly phosphorylate the SH3-SH2 …
leukemia. Recently, we observed that inhibition of myeloid Src family kinase activity (eg Hck,
Lyn, and Fyn) induces growth arrest and apoptosis in Bcr-Abl-transformed cells, suggesting
that cell transformation by Bcr-Abl involves Src family kinases (Wilson, MB, Schreiner, SJ,
Choi, HJ, Kamens, J., and Smithgall, TE (2002) Oncogene 21, 8075-8088). Here, we report
the unexpected observation that Hck, Lyn, and Fyn strongly phosphorylate the SH3-SH2 …
