Emerging roles for cyclooxygenase‐2 in gastrointestinal mucosal defense
JL Wallace, PR Devchand - British journal of pharmacology, 2005 - Wiley Online Library
British journal of pharmacology, 2005•Wiley Online Library
The development of selective inhibitors of cyclooxygenase‐2 (COX‐2) was based on the
concept that this enzyme played little, if any, role in modulating the ability of the
gastrointestinal (GI) tract to resist and respond to injury. There is now overwhelming
evidence that this is far from true. Indeed, COX‐2 mediates several of the most important
components of 'mucosal defense', contributes significantly to the resolution of GI
inflammation and plays a crucial role in regulating ulcer healing. COX‐2 also contributes to …
concept that this enzyme played little, if any, role in modulating the ability of the
gastrointestinal (GI) tract to resist and respond to injury. There is now overwhelming
evidence that this is far from true. Indeed, COX‐2 mediates several of the most important
components of 'mucosal defense', contributes significantly to the resolution of GI
inflammation and plays a crucial role in regulating ulcer healing. COX‐2 also contributes to …
The development of selective inhibitors of cyclooxygenase‐2 (COX‐2) was based on the concept that this enzyme played little, if any, role in modulating the ability of the gastrointestinal (GI) tract to resist and respond to injury. There is now overwhelming evidence that this is far from true. Indeed, COX‐2 mediates several of the most important components of ‘mucosal defense’, contributes significantly to the resolution of GI inflammation and plays a crucial role in regulating ulcer healing. COX‐2 also contributes to long‐term changes in GI function after bouts of inflammation.
British Journal of Pharmacology (2005) 145, 275–282. doi:10.1038/sj.bjp.0706201
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