The effects of sulfonylurea glyburide on superoxide dismutase, catalase, and glutathione peroxidase activities in the brain tissue of streptozotocin-induced diabetic rat
NK Nazaroglu, A Sepici-Dincel, N Altan - Journal of Diabetes and its …, 2009 - Elsevier
OBJECTIVES: A member of the second-generation sulfonylureas, glyburide (GLY;
glibenclamide) provides an effective therapy for patients with type 2 diabetes. It stimulates
pancreatic insulin secretion, suggesting that it is effective in the treatment of type 2 diabetes
primarily by elevating the circulating insulin levels. However, experimental evidences have
indicated that sulfonylureas have also had an extrapancreatic effect, which may directly
contribute toward maintaining blood glucose homeostasis during diabetes. METHODS: In …
glibenclamide) provides an effective therapy for patients with type 2 diabetes. It stimulates
pancreatic insulin secretion, suggesting that it is effective in the treatment of type 2 diabetes
primarily by elevating the circulating insulin levels. However, experimental evidences have
indicated that sulfonylureas have also had an extrapancreatic effect, which may directly
contribute toward maintaining blood glucose homeostasis during diabetes. METHODS: In …