In vitro and in vivo antioxidant properties of gliclazide
RC O'Brien, M Luo, N Balazs, J Mercuri - Journal of Diabetes and its …, 2000 - Elsevier
Diabetes is a state of increased oxidant stress and there is evidence that oxidation may play
a role in the genesis of complications. Gliclazide, a sulfonylurea hypoglycemic drug, has
been shown to possess free radical scavenging properties. This study examined the effects
of in vitro supplementation with gliclazide and other sulfonylureas as on low-density
lipoprotein (LDL) oxidation and the total plasma antioxidant capacity (TPAC). In a separate
study, the effects of 10 months of oral gliclazide therapy on oxidative parameters were …
a role in the genesis of complications. Gliclazide, a sulfonylurea hypoglycemic drug, has
been shown to possess free radical scavenging properties. This study examined the effects
of in vitro supplementation with gliclazide and other sulfonylureas as on low-density
lipoprotein (LDL) oxidation and the total plasma antioxidant capacity (TPAC). In a separate
study, the effects of 10 months of oral gliclazide therapy on oxidative parameters were …