[HTML][HTML] Differential control of the CCAAT/enhancer-binding protein β (C/EBPβ) products liver-enriched transcriptional activating protein (LAP) and liver-enriched …
Y Li, E Bevilacqua, CB Chiribau, M Majumder… - Journal of Biological …, 2008 - ASBMB
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers a stress
response program that protects cells early in the response and can lead to apoptosis during
prolonged stress. The basic leucine zipper transcription factor, CCAAT/enhancer-binding
protein β (C/EBPβ), is one of the genes with increased expression during ER stress.
Translation of the C/EBPβ mRNA from different initiation codons leads to the synthesis of two
transcriptional activators (LAP-1 and− 2) and a transcriptional repressor (LIP). The LIP/LAP …
response program that protects cells early in the response and can lead to apoptosis during
prolonged stress. The basic leucine zipper transcription factor, CCAAT/enhancer-binding
protein β (C/EBPβ), is one of the genes with increased expression during ER stress.
Translation of the C/EBPβ mRNA from different initiation codons leads to the synthesis of two
transcriptional activators (LAP-1 and− 2) and a transcriptional repressor (LIP). The LIP/LAP …