Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions
B Korkmaz, T Moreau, F Gauthier - Biochimie, 2008 - Elsevier
Polymorphonuclear neutrophils form a primary line of defense against bacterial infections
using complementary oxidative and non-oxidative pathways to destroy phagocytized
pathogens. The three serine proteases elastase, proteinase 3 and cathepsin G, are major
components of the neutrophil primary granules that participate in the non-oxidative pathway
of intracellular pathogen destruction. Neutrophil activation and degranulation results in the
release of these proteases into the extracellular medium as proteolytically active enzymes …
using complementary oxidative and non-oxidative pathways to destroy phagocytized
pathogens. The three serine proteases elastase, proteinase 3 and cathepsin G, are major
components of the neutrophil primary granules that participate in the non-oxidative pathway
of intracellular pathogen destruction. Neutrophil activation and degranulation results in the
release of these proteases into the extracellular medium as proteolytically active enzymes …
