Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis
HR Choi, JG Batsakis, F Zhan, E Sturgis, MA Luna… - Human pathology, 2002 - Elsevier
p73 and p63 are recently cloned genes that share considerable structural and functional
homologies with the p53 tumor suppressor gene. These genes, unlike p53, express multiple
mRNA isoforms with variable biologic functions, and their suppressor nature has yet to be
confirmed. To determine the interrelationship between these genes in the tumorigenesis of
head and neck squamous carcinoma (HNSC), we performed immunohistochemical
analyses of their protein products and compared the data with clinicopathologic parameters …
homologies with the p53 tumor suppressor gene. These genes, unlike p53, express multiple
mRNA isoforms with variable biologic functions, and their suppressor nature has yet to be
confirmed. To determine the interrelationship between these genes in the tumorigenesis of
head and neck squamous carcinoma (HNSC), we performed immunohistochemical
analyses of their protein products and compared the data with clinicopathologic parameters …
