[HTML][HTML] Gene Array and Protein Expression Profiles Suggest Post-transcriptional Regulation during CD8+ T Cell Differentiation* 210
CM Cham, H Xu, JP O'Keefe, FV Rivas… - Journal of Biological …, 2003 - ASBMB
Peripheral CD8+ T cells circulate in a quiescent naive state until they are primed by specific
antigen and differentiate into effector cells. In the effector state, CD8+ T cells acquire cytolytic
activity and produce increased levels of cytokines such as interferon-γ. They also exhibit
increased T cell receptor sensitivity, decreased CD28 dependence, and become inhibitable
by CTLA-4 and other negative regulatory pathways. We hypothesized that one mechanism
by which these two states are regulated is via differential expression of specific genes. To …
antigen and differentiate into effector cells. In the effector state, CD8+ T cells acquire cytolytic
activity and produce increased levels of cytokines such as interferon-γ. They also exhibit
increased T cell receptor sensitivity, decreased CD28 dependence, and become inhibitable
by CTLA-4 and other negative regulatory pathways. We hypothesized that one mechanism
by which these two states are regulated is via differential expression of specific genes. To …
