Telomere length in Hutchinson-Gilford progeria syndrome
ML Decker, E Chavez, I Vulto, PM Lansdorp - Mechanisms of ageing and …, 2009 - Elsevier
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused
by mutations in the gene LMNA, which encodes the nuclear matrix protein lamin A. Previous
research has shown that the average telomere length in fibroblasts from HGPS patients is
shorter than in age-matched controls. How mutations in lamin A lead to shortened telomere
lengths is not known nor is the contribution of individual chromosome ends to the low
average length understood. To measure the telomere length of individual chromosomes, we …
by mutations in the gene LMNA, which encodes the nuclear matrix protein lamin A. Previous
research has shown that the average telomere length in fibroblasts from HGPS patients is
shorter than in age-matched controls. How mutations in lamin A lead to shortened telomere
lengths is not known nor is the contribution of individual chromosome ends to the low
average length understood. To measure the telomere length of individual chromosomes, we …