A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity
M Liu, CC Chien, M Burne-Taney… - Journal of the …, 2006 - journals.lww.com
Recent evidence supports a role for an inflammatory pathogenesis of cisplatin
nephrotoxicity, but immune cell–mediated mechanisms in this disease are still largely
unknown. The role for T lymphocytes on cisplatin-induced acute kidney injury was examined
with C57BL/6 T cell–deficient (nu/nu) mice and CD4-or CD8-deficient mice and their wild-
type (WT) littermates. All mice received a single dose of cisplatin at 40 mg/kg
(intraperitoneally) and were followed up for 72 h. At 72 h after cisplatin administration, T cell …
nephrotoxicity, but immune cell–mediated mechanisms in this disease are still largely
unknown. The role for T lymphocytes on cisplatin-induced acute kidney injury was examined
with C57BL/6 T cell–deficient (nu/nu) mice and CD4-or CD8-deficient mice and their wild-
type (WT) littermates. All mice received a single dose of cisplatin at 40 mg/kg
(intraperitoneally) and were followed up for 72 h. At 72 h after cisplatin administration, T cell …