[HTML][HTML] Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38 …
EJ Ryer, K Sakakibara, C Wang, D Sarkar… - Journal of Biological …, 2005 - ASBMB
Apoptotic death of vascular smooth muscle cells (SMCs) is a prominent feature of blood
vessel remodeling. In the present study, we examined the novel PKC isoform protein kinase
C delta (PKCδ) and its role in vascular SMC apoptosis. In A10 SMCs, overexpression of
PKCδ was sufficient to induce apoptosis, whereas inhibition of PKCδ diminished H 2 O 2-
induced apoptosis. Moreover, evidence is provided that the tumor suppressor p53 is an
essential mediator of PKCδ-induced apoptosis in SMCs. Activation of PKCδ led to …
vessel remodeling. In the present study, we examined the novel PKC isoform protein kinase
C delta (PKCδ) and its role in vascular SMC apoptosis. In A10 SMCs, overexpression of
PKCδ was sufficient to induce apoptosis, whereas inhibition of PKCδ diminished H 2 O 2-
induced apoptosis. Moreover, evidence is provided that the tumor suppressor p53 is an
essential mediator of PKCδ-induced apoptosis in SMCs. Activation of PKCδ led to …