Pathophysiology of the lymphatic drainage of the central nervous system: Implications for pathogenesis and therapy of multiple sclerosis
In most organs of the body, immunological reactions involve the drainage of antigens and
antigen presenting cells (APCs) along defined lymphatic channels to regional lymph nodes.
The CNS is considered to be an immunologically privileged organ with no conventional
lymphatics. However, immunological reactions do occur in the CNS in response to infections
and in immune-mediated disorders such as multiple sclerosis (MS) and experimental
autoimmune encephalomyelitis (EAE). Here, we review evidence that cervical lymph nodes …
antigen presenting cells (APCs) along defined lymphatic channels to regional lymph nodes.
The CNS is considered to be an immunologically privileged organ with no conventional
lymphatics. However, immunological reactions do occur in the CNS in response to infections
and in immune-mediated disorders such as multiple sclerosis (MS) and experimental
autoimmune encephalomyelitis (EAE). Here, we review evidence that cervical lymph nodes …