[HTML][HTML] p53 and Sp1 Interact and Cooperate in the Tumor Necrosis Factor-induced Transcriptional Activation of the HIV-1 Long Terminal Repeat (∗)
A Gualberto, AS Baldwin - Journal of Biological Chemistry, 1995 - ASBMB
Tumor necrosis factor α (TNF) is a potent activator of transcription directed by the human
immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR). We have recently
reported that the p53 tumor suppressor gene product binds to a site within the Sp1 binding
region of the HIV-1 LTR and contributes to the TNF induction of this promoter. In this study
we show that the transcription factor Sp1 cooperates with p53 in the transcriptional activation
directed by the HIV-1 LTR. The presence of Sp1 increased p53 binding to its recognition …
immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR). We have recently
reported that the p53 tumor suppressor gene product binds to a site within the Sp1 binding
region of the HIV-1 LTR and contributes to the TNF induction of this promoter. In this study
we show that the transcription factor Sp1 cooperates with p53 in the transcriptional activation
directed by the HIV-1 LTR. The presence of Sp1 increased p53 binding to its recognition …
