HMGB1 and HMGB2 cell-specifically down-regulate the p53-and p73-dependent sequence-specific transactivation from the human Bax gene promoter
M Stros, T Ozaki, A Bacıková, H Kageyama… - Journal of Biological …, 2002 - ASBMB
The recently cloned genep73 is a close homologue of p53, which is a crucial tumor
suppressor gene for preventing the malignant transformation of cells by inducing cell cycle
arrest and apoptosis. Previous reports have shown that architectural DNA-bending/looping
chromosomal proteins HMGB1 and HMGB2 (formerly known as HMG1 and HMG2), which
function in a number of biological processes including transcription and DNA repair, interact
in vitro with p53 and stimulate p53 binding to DNA containing p53 consensus sites. Here, we …
suppressor gene for preventing the malignant transformation of cells by inducing cell cycle
arrest and apoptosis. Previous reports have shown that architectural DNA-bending/looping
chromosomal proteins HMGB1 and HMGB2 (formerly known as HMG1 and HMG2), which
function in a number of biological processes including transcription and DNA repair, interact
in vitro with p53 and stimulate p53 binding to DNA containing p53 consensus sites. Here, we …
