A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway
T Spies, M Bresnahan, S Bahrain, D Arnold, G Blanck… - Nature, 1990 - nature.com
T Spies, M Bresnahan, S Bahrain, D Arnold, G Blanck, E Mellins, D Pious, R DeMars
Nature, 1990•nature.comMAJOR histocompatibility complex (MHC) class I molecules export peptides to the cell
surface for surveillance by cytotoxic T lymphocytes1-3. Intracellular peptide binding is critical
for the proper assembly and transport of class I molecules4–6. This mechanism is impaired
as a result of a non-functional peptide supply factor gene (PSF) in several human mutant cell
lines with genomic lesions in the MHC. We have now identified PSF in the MHC class II
region by deletion mapping in mutants and chromosome-walking. PSF is homologous to …
surface for surveillance by cytotoxic T lymphocytes1-3. Intracellular peptide binding is critical
for the proper assembly and transport of class I molecules4–6. This mechanism is impaired
as a result of a non-functional peptide supply factor gene (PSF) in several human mutant cell
lines with genomic lesions in the MHC. We have now identified PSF in the MHC class II
region by deletion mapping in mutants and chromosome-walking. PSF is homologous to …
Abstract
MAJOR histocompatibility complex (MHC) class I molecules export peptides to the cell surface for surveillance by cytotoxic T lymphocytes1-3. Intracellular peptide binding is critical for the proper assembly and transport of class I molecules4–6. This mechanism is impaired as a result of a non-functional peptide supply factor gene (PSF) in several human mutant cell lines with genomic lesions in the MHC. We have now identified PSF in the MHC class II region by deletion mapping in mutants and chromosome-walking. PSF is homologous to mammalian and bacterial ATP-dependent transport proteins, suggesting that it operates in the intracellular transport of peptides.
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